Both are MHRA-approved, supported by large Phase 3 clinical trials, and available on prescription in the UK
In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)
Annual cancer progression risk: 0.6% (1 in 167) Five year risk for either HGD or cancer: 1.5% (1 in 67) Cells may be dysplastic, but the [.text-color-brand-blue][#tip-9]pathologist[#tip-9][.text-color-brand-blue] is not certain In 4% to 8% of biopsies, the presence of dysplasia may be hard to determine with certainty, often because morphological changes associated with less-advanced dysplasia are so small, and may be difficult to distinguish from inflammation
B12 is an essential nutrient, and its deficiency is common, especially among individuals following restricted diets like vegetarianism or veganism, pregnant or breastfeeding women, older adults, those who have undergone gastrointestinal surgery or have gastrointestinal disorders, and people with an autoimmune condition known as pernicious anaemia
Researchers hope that larger clinical investigations will clarify the peptide's pharmacology, safety profile, and biological significance
