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80 In an uncontrolled trial with 30 participants, a topical 4% quassia gel, used daily for six weeks, led to improvement in rosacea symptoms such as flushing, redness, papules, pustules, and telangiectasia

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Spermidine Like TMG, spermidine has its own suite of anti-aging benefits.39 And as a polyamine, its presence can balance against the activity of N-nicotinamide methyltransferase (NNMT), which can redirect NAM out of the salvage pathway and convert it to more harmful byproducts associated with various markers of metabolic disorders.40 41 Research points toward 15mg as a reliable dose, with lower doses performing suboptimally