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560 The structural versatility required to accommodate binding of a broad range of ligands to different sites coupled with the wide distribution of oxidation-sensing Cys residues and low overall sequence similarity among MarR regulators, collectively suggest a model where ligand binding induces a conformational change in the homodimer that cannot be explained by a single sensing site and accompanying pathway of allosteric communication

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And maintaining the so-called integrity of that structural fat, meaning the health of those neurons, is going to come in large part from the foods that we eat