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Following this treatment plan helps doctors manage severe vitamin B12 deficiency in adults

While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition

[113] Currently, radioisotope dilution assay (RIDA) with labeled vitamin B 12 and hog IF (pigs) have been used to determine vitamin B 12 content in food

Key points: Formulation: Most commonly, cyanocobalamin or hydroxocobalamin in aqueous solution is used