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The USPSTF recommends that clinicians direct patients who use tobacco to other tobacco cessation interventions with proven effectiveness and established safety (Table 1)

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Smoked cigarette butts: Unignorable source for environmental microplastic fibers Sci Tot Enviro 2021 Jun 9;791:148384

Thus, the use of liquid application dosing may invalidate the use of pro-inflammatory cytokine release as an in vitro biomarker that is directly linked to in vivo mediators of toxicity

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