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Acknowledgements This work was supported by the National Institute for Diabetes and Digestive and Kidney Diseases (F30 award DK117570, T32 award DK108735-01)

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Hyperglycaemia is associated with dyslipidemia and alterations in the cardiovascular tone, and combination therapy offers a range of pharmacological activity by lowering plasma glucose and improving liver gluconeogenesis and lipid parameters

However, the efficacy of nasal sprays may vary compared to injectable or oral methods

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