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In fact in a murine, reversible, UUO model, (characterized by regression of established tubulointerstitial fibrosis after reversal of obstruction), scRNA-seq study revealed the different roles of macrophages in the progression of kidney fibrosis mediated by their polarization into a variety of phenotypes [119]

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Disruption of the rumen microbial network can shift metabolism into pathological states

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The temperature during the formation of the emulsion is not especially critical but in some cases, influences the size and quality of the microspheres and the solubility of the drug in the continuous phase