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Beyond malignant epithelial cells, the TME encompasses hypoxic niches, infiltrating immune cells, stromal fibroblasts, and an aberrant extracellular matrixall of which converge to drive resistance to standard therapies, including brachytherapy [27, 28]

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This property of TME can be well utilized in targeting a mild-hyperthermia-based drug loading system to cancer cells

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Eye bag removal often requires different approaches, including treatments that address fluid retention, fat deposits, or muscle laxity rather than just pigmentation