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The administration of vasopressin (1 IU/kg, i.v.) to the rats elevated the S-wave level of the electrocardiogram reflecting the presence of subendocardial ischemia, whereas it decreased of the heart rate, resulting in the increase of the cardiac enzymes, creatine kinase MB (CK MB), and lactate dehydrogenase (LDH)

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I have used drugs well beyond their expiry date ever since without any adverse effects