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Concurrently, unmetabolized fatty acids accumulate intracellularly, contributing to lipid overload and lipotoxicity [39]

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Supplementary information Rights and permissions About this article Cite this article Wang, H., Du, Ys., Xu, Ws

Together, these finding indicate that the toxic effects of DOX on the heart are strongly associated with iron overload and ferroptosis in mitochondria, indicating that targeting ferroptosis could serve as a promising therapeutic strategy for protecting the hearts of cancer patients from DOX-induced cardiomyopathy

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