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Another advantage of using a biomaterial scaffold as opposed to traditional administration routes such as IV is that the drug delivery is more localized, meaning that there is less accumulation of the drug in areas other than directly at the tumor site, constituting less damage to healthy tissue and thus reducing adverse effects ( 4.1.1 Impact of chemotherapy on the TME Chemotherapy drugs target many aspects of cell physiology, including DNA replication, RNA synthesis, cell structure and metabolism

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