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Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, transient elevations in serum amylase, and opioid-induced esophageal dysfunction (OIED)

While CYP51A1 overexpression is frequently associated with cancer progression, emerging strategies explore the potential therapeutic benefit of its hyperactivation under select conditions

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Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI

For people who cannot tolerate GI side effects or who have medical conditions that make GLP-1 agonists risky, this safety differential is not a minor footnote