J Nutr Health Aging 20(8):825834
3.6 Ferroptosis: iron-dependent cell death Ferroptosis, a non-apoptotic form of regulated cell death involving iron ions and lipid peroxidation, is characterized primarily by the accumulation of lipid peroxides in the cell membrane ( Recent studies have indicated that ferroptosis, as an important mechanism of melanocyte destruction, not only directly leads to cell death but also intensifies the inflammatory response and immune dysregulation in vitiligo by enhancing oxidative stress and activating innate immune pathways ( + T cell response against melanocytes
In addition, further exploration is necessary to identify the molecular switches of tumor cells that activate alternative metabolic pathways (e.g., Glycolysis or Fatty acid oxidation) in response to glutamine deprivation
These models replicate pathological conditions such as POI, polycystic ovary syndrome, and iatrogenic ovarian failure through diverse approaches, including chemical, nutritional, surgical, genetic, and toxicological methods
Glutathione l mt nhn t quan trng trong vic duy tr ln da khe mnh, ti sng v rng r 1
