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Additionally, the application of PCs to rat retinal capillary endothelial cells (TR-iBRB2) decreases oxidative stress and inflammasome activation, suggesting involvement of the oxidase/NF-B/NLRP3 axis in mediating their cytoprotective effects (Zou et al., 2023)

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[9] Conversely, excessive intracellular zinc can initiate apoptosis through mitochondrial dysfunction and antagonize copper-dependent enzymes, underscoring the importance of precise dosing in parenteral formulations

Finally, through the - stacking interaction between the aromatic rings, sorafenib is co-loaded onto the graphdiyne nanosheets

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