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We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

In a healthy woman's blood plasma, these two isomers exist in a highly specific physiological balance of roughly 40 to 1

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10.1096/fj.201801860RR FASEB J

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