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Such molecules may be appropriate for use at the first indication of mild cognitive impairment, and perhaps prophylactically in those individuals who are most likely to develop dementia due to genetic, health, behavioral and life-style predisposing factors
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Stimulation assays for testing the effects of activity on the localization of SVs Surface epitopes of Syt1 were saturated by incubating the neurons in divalent-free buffer (Tyrode buffer without Mg 2+ and Ca 2+ ) with HaloTag-free NbLumSyt1 for 5 min at 37 C
Dosing is individualized, but a typical protocol titrates from a starting dose up to a target dose over 2 to 4 weeks, injected 5 days on and 2 days off, in defined cycles with scheduled breaks between them