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Oxidative stress is an imbalance of free radicals and antioxidants in the body
PMID: 42346097 Cell Rep Methods RECOVER identifies synergistic drug combinations in vitro through sequential model optimization
The elevated GSH level helps to prevent apoptosis of cancer cells by detoxifying reactive oxygen species (ROS) [3] and induce chemotherapeutic drugs resistance through GSH spontaneous reactions or xenobiotics reactions catalyzed by GSH S-transferase (GST) [4, 5]
This is the practical reason a reader who is nervous about small-volume accuracy might prefer the 50 mg protocol the trade-off being that each vial carries fewer total doses, as the supply math shows next
If the ability to reduce GSSG to GSH is overwhelmed by a high burden of oxidative stress, GSSG can be exported out of cells or react with protein sulphydryl groups to prevent a major shift in the redox equilibrium [11], thereby depleting cellular GSH
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