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In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]

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Comparing AOD 9604 and tirzepatide weight loss outcomes requires acknowledging that these compounds were tested under different conditions, for different durations, and with different outcome measures