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And the action of them can be affected by iron-responsive element-binding protein 2 (IREB2)

While these bacterial enzymes have been explored for the generation of natural product analogs or applications in biocatalysis, the broad utility of amide bond-forming enzymes in enzymatic combinatorial synthesis has not been fully realized because of unwanted cross-reactivities of the enzymes toward substrates and/or difficulties in finding partnering enzymes with comparable substrate promiscuity 56

Supplementary Data 8 (download XLSX Statistical source data for Supplementary Fig

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Qin X, Xin Y, Zou J, Su X, Wang X, Wang Y, Zhang J, Tu T, Yao B, Luo H, Huang H (2021b) Efficient degradation of aflatoxin B1 and zearalenone by laccase-like multicopper oxidase from Streptomyces thermocarboxydus in the presence of mediators