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Nicotine is known to rapidly metabolize into cotinine and OH-Cotinine, indirectly contributing to more heightened ROS accumulation 53,54

However, the authors also emphasize that these studies only amount to a level of limited evidence, and that [w]hether or not the levels of exposure are high enough to contribute to human carcinogenesis remains to be determined. Additionally, [t]here is no available evidence whether or not e-cigarette use is associated with intermediate cancer endpoints in humans, the report says

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The national average for unleaded is $3.274 per gallon, according to Patrick De Haan, head of petroleum analysis at GasBuddy, who posted Monday Nov