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In some instances, an increase in concentration of an active agent in the otic formulation saturates the clearance process and allows for a more rapid and stable steady state to be reached

Luque RM, Huang ZH, Shah B, Mazzone T, Kineman RD

It has been shown to reduce visceral adipose tissue by 15-20% in clinical trials

these studies also found positive correlations between plasma GABA levels and severity of autistic symptoms, including levels of hyperactivity and tactile sensitivity(Alabdali et al., 2014