The NHS schedule for treating a confirmed deficiency shows why dosing is not guesswork
Using a standard curve, the NO level was calculated and reported as nmol/mL or nmol/g of tissue
the newer 7.2 mg dose approved in January 2026 produces around 20%
Markar SR , Sgromo B, Evans R, Griffith EA, Alfieri R, Castoro C, Gronnier C, Gutschow CA, Piessen G, Capovilla G, Grimminger PP, Low DE, Gossage J, Gisbertz SS, Ruurda J, van Hillegersberg R, D'journo XB, Phillips AW, Rosati R, Hanna GB, Maynard N, Hofstetter W, Ferri L, Berge Henegouwen MI, Owen R
However, deficiency in either SMARCA4, SMARCB1 or PBRM1 attenuates recruitment of these transcription factors, thereby repressing expression of SLC7A11 , which then reduces transport of cystine into cells