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For Tirzepatide users specifically, this combination helps preserve lean mass while the primary medication handles fat reduction

Tirzepatide may have serious side effects, including possible thyroid tumors

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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Peptide therapy is emerging as a powerful tool to reset metabolism, balance hunger hormones, and promote fat loss while supporting lean muscle