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Peer review Peer review information Nature Reviews Neurology thanks Hlio Teive, Ludger Schls and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

The primary intended use of AOD-9604 centers on its ability to enhance fat metabolism through specific cellular mechanisms

A combination of both strategies can offer the best of both worlds: cost-efficiency from index funds and potential outperformance from actively managed funds

This dual action, increasing fat breakdown while simultaneously reducing new fat formation, has been observed in multiple rodent adipocyte models and provides a mechanistically distinct experimental profile compared to compounds that affect only one arm of fat metabolism

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