For pregnancy and breastfeeding, the EFSA assumes an extra 0.2 g and 0.4 g of daily absorbed B12, respectively
[Google Scholar] 91.Mizuno K., Tanaka M., Yamaguti K., Kajimoto O., Kuratsune H., Watanabe Y
NAD+ Preservation and Sirtuin Activation First and most directly, NNMT activity consumes nicotinamide, which is a key precursor for NAD+ biosynthesis through the salvage pathway (the predominant NAD+ synthesis route in most mammalian cells)
Karas L, Asif M, Chun V, Khan FA
NICE and BNF Guidance: You correctly point out that even official guidance from NICE and the BNF acknowledges that some individuals may require more frequent injections