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DOI: 10.1016/S0169-409X(96)00423-1 Accordingly, in silico approaches to solubility prediction have been a focus of computer-assisted drug design for decades
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ROS active many signaling kinases (e.g., mitogen activated protein kinases), transcription factors (e.g., nuclear factor kB [NF-kB] and nuclear factor of activated T-cells [NFAT]), molecules that participate in calcium mobilization (e.g., ryanodine receptors [RyR2], SERCA 2A, calcium/calmodulin-dependent protein kinase II [CaMKII]), antioxidant proteins and others molecules involved in cardiac hypertrophy [151,152]
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