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The deficiency was more severe than expected People with advanced B12 deficiency, especially with neurological symptoms, often feel rough at the start of treatment because the underlying problem was significant

That being said, some treatments prove to be more helpful than others, and addressing alcohols impact on your levels of Vitamin B12 is one of them

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With regard to substitution in cases of existing B12 deficiency, the fact that B12 sensitisation is mainly triggered by injections makes it advisable to avoid intramuscular administration

Standard Dosing Ranges The most extensively studied dosing protocols for subcutaneous administration include: Research-Based Dosing Protocols Beginner/Conservative Protocol: Dose: 250-300 mcg once daily Duration: 4-8 weeks initial assessment period Rationale: Allows tolerance assessment and response evaluation at lower end of therapeutic range Standard Protocol: Dose: 300-500 mcg once daily Duration: 12-24 weeks based on clinical trials Rationale: Most commonly studied range in human research with optimal benefit-to-safety ratio Advanced Protocol: Dose: 500 mcg-1 mg once daily Duration: 12-24 weeks under close medical monitoring Rationale: Upper clinical range