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First, the cross-sectional design captures associations at a single point in time and therefore precludes causal inference

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Retrieved 14 March 2013

We characterized the impact of nAChR agonists on brain function using the ALE framework (paralleling that described above) and separately identified brain regions showing either convergent activity increases or decreases using a cluster-level corrected threshold ( p corrected 4000 compounds present in tobacco smoke [67], and/or be mediated directly or indirectly by nicotine itself