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Chitosan-coated liposomes carrying peptide payloads have shown enhanced mucoadhesion and epithelial uptake, with prolonged plasma exposure compared to unformulated sublingual solutions

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The FDA also notes that no safety-related information regarding DSIP has been identified, so its unknown whether it could be harmful to humans.26 Given these conclusions, we shouldnt be surprised that DSIP is not an FDA-approved peptide therapy