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2.1.1 PINK1/parkin-mediated mitophagy PTEN-induced putative kinase 1 (PINK1) is an outer mitochondrial membrane (OMM) kinase, whereas Parkin is an E3 ubiquitin ligase present in the cytosol, both of which are gene products mutated in Parkinsons disease (Valente et al., 2004

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