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Lastly, although it has been shown that GABA is an HDACi in a neuroblastoma cell line (Xing et al., 2019), in our hands, GABA does not inhibit HDACs to a detectable level in colonic epithelial cells (unpublished)

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VPA is used to treat psychiatric disorders and as such there is an association with accidental or deliberate overdose, the incidence of which is increasing [135, 136]

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