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Creatine-related water shifts are often described as occurring within muscle tissue, but individual responses and appearance changes can vary

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Further studies, including more severe stages of DSPN are needed to confirm these suggestions

The tracing of any symptom connoting nociplastic features of pain such as unrefreshed sleep or sleep disorders, fatigue, migratory and non-consistent pain, various somatic symptoms etc., led to the exclusion of the patients from the non-FM NP group