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Treatment increased beneficial Bacteroides acidifaciens and reduced pathogenic Clostridiales bacterium and Proteobacteria

Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients

A novel bacterium called Ihubacter massiliensis was also discovered to be a key microbe for TMA/TMAO production by using an OCCT-based humanized gnotobiotic mice model

In detoxified alcoholics, it has been shown to decrease the rate of relapse, maintain abstinence, and decrease the severity of relapse when it occurs

However, it can cause irritation and result in redness, itching and inflammation