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The practical result, in our clinical experience, is that patients with a subacute tendinopathy that has stalled at 6 to 12 weeks of physical therapy tend to notice a meaningful change in pain level and range of motion within 3 to 4 weeks of starting a BPC-157 protocol

The peptide's short plasma half-life (estimated at several minutes for the native peptide) likely limits systemic accumulation

Kannengiesser K, Maaser C, Heidemann J, Luegering A, Ross M, Brzoska T, Bohm M, Luger TA, Domschke W, Kucharzik T

D., Clemmensen, C., Finan, B., DiMarchi, R

Summary: Jitteriness is not a recognised side effect of Mounjaro (tirzepatide) according to UK regulatory data, though some patients report shakiness due to indirect factors such as low blood sugar or reduced food intake