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Others are modified versions, as with many of the blockbuster GLP-1 weight loss drugs

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2 While all forms of B12 are well-tolerated by many, methylcobalamin is the form of B12 that is most known for causing some mild side effects related to methylation

By inhibiting NNMT, it alters the balance of S-adenosylmethionine (SAM) and nicotinamide metabolism, affecting DNA methylation patterns and histone modifications