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HPLC enables the precise quantification of lipid hydroperoxides, while MS, particularly with Na adducts and collision-induced dissociation (CID), facilitates the identification of hydroperoxide positions and diastereomers, enhancing our understanding of lipid oxidation in vivo (Kontogianni & Gerothanassis, 2022

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For instance, inhibitors of GSH synthesis, such as buthionine sulfoximine in laboratory studies, can enhance the killing effect of antibiotics