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One long-term trial found that taking 800mg daily for four years improved CRP levels and glucose control.36 1,2001,800mg/day Higher doses in this range have been explored in short-term studies, particularly for more advanced cases of neuropathy or obesity

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Probucol, a lipid-lowering agent, also exhibits antioxidant properties that reduce intracellular oxidative stress and maintain normal cellular redox state by upregulating Nrf2 and GPX4 protein expression, thereby enhancing cardiomyocyte antioxidant capacity