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Immunological abnormalities as potential biomarkers in chronic fatigue Syndrome/Myalgic encephalomyelitis

PMID 19255021

Ensuring support for research, development and validation of novel biomarker tests Research advancements on clinical assessments, psychometric testing, and emerging bloodbased and established biomarker tests are increasing the likelihood of being able to detect hallmarks of neurodegenerative diseases at their earliest stages

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At the cellular level, many neurotrophic factors stimulate activation of tropomyosin-related kinase (Trk) receptors, including type A and B, which in turn activates intracellular signaling cascades that regulate NSC self-renewal and fate specification [28]