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Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells
depending on the concentration
PEG precipitation or selected antibodies immunoprecipitation)
and uterine cells
as a glycosyl phosphatidyl inositol (GPI) anchored protein in granulocytes and as an integral membrane protein on NK cells and macrophages
anti-ZBP1, mAb (Zippy-1) 285983-48-4 Proteoglycans mediate binding of APRILZBP1 is an interferon inducible protein that binds to cytoplasmic DNA and plays a role in host defense against tumors and pathogens. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. ZBP1 is an innate immune sensor of Influenza A virus (IAV). ZBP1 regulates NLRP3 (nucleotide and oligomerization domain, leucine rich repeat containing protein family, pyrin domain containing 3) inflammasome
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