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Murine middle cerebral artery occlusion (MCAO) stroke model The MCAO model was used to induce an acute stroke in situ as described previously 2

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The binary gradient used was as follows: 01.0 min (016% B), 1.04.5 min (1622% B), 4.54.6 min (22100% B), 4.66.6 min (100% B), and 6.78.0 min (0% B)