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If a patient is suspected to be experiencing OIH, carefully consider appropriately decreasing the dose of the current opioid analgesic, or opioid rotation (safely switching the patient to a different opioid moiety) (see DOSAGE AND ADMINISTRATION, WARNINGS)

These effects appear to be independent of thyroid hormone levels, reinforcing the idea that the inflamed thyroid gland may itself contribute to symptom persistence via immune-mediated mechanisms

Thus far, a physiologically relevant signaling molecule capable of binding the pVSD remains to be identified

Several causative mutations in multiple genes have been described to date

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