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By activating pathways involved in glucose uptake and mitochondrial efficiency, MOTS-c may help support insulin sensitivity and metabolic flexibility

The cause of B12 deficiency, vegetarian diet, pregnancy, and breastfeeding, can impact the dosage and duration of therapy

doi: 10.1212/WNL.0000000000002699 117 Ben AssayagEEldorRKorczynADKliperEShenhar-TsarfatySTeneOet al

Although gastric banding carries a lower risk of B12 deficiency than malabsorptive procedures such as Roux-en-Y bypass, reduced tolerance of B12-rich foods and the use of acid-suppressing medicines can still compromise nutritional status over time

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