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doi:10.1016/j.lfs.2019.117139 Deng M, Zhang Q, Yan L, et al

Sometimes a combination of two diuretics is given as it can be significantly more effective than either compound alone, the reason being that one nephron segment can compensate for altered sodium reabsorption at another nephron segment

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The standard 80 mg vial supports about 30 daily injections at the 22.5-unit (0.225 mL) ceiling, or 40 daily injections at the 15-unit maintenance volume