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Food, drink, smoking, and even pH levels in the mouth affect absorption

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However, the pediatric acute liver failure study group has found that in chronic exposure to APAP (in contrast to a single toxic dose), younger patients (median age, 3.5 years) experienced a greater level of hepatotoxicity comparative to older adolescent patients (median age 15.2 years) who were more likely to experience hepatotoxicity from a single toxic dose (Rumack et al., 1981)

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The agency cited immunogenicity concerns, saying there was limited data on the quality, stability and consistency of the compounds