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In some embodiments, the otic formulation or composition comprises between about 1% to about 40% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

In the case of thrombosis, rapid diagnosis and prompt initiation of anticoagulant treatment are essential

2 This increase in inflammatory cytokines appears to have a significant effect on downstream inflammation, as IL-6 was recently shown to play a key role in the pulmonary inflammatory response of alcoholic mice in a burn injury model

Short-term studies suggest favorable safety characteristics

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