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Concurrently, controlled delivery vehicles such as lipid or polymer-based nanoparticles and exosome-mimetic vesicles are being engineered to deliver metabolic modulators directly to intratumoral MDSCs, thereby enhancing the local potency while minimizing systemic toxicity (200)

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Maat, D., van der Veen, C., & Beerens, M

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This article covers the circadian receptor expression patterns that determine KLOW's metabolic action, the specific timing windows that maximize each outcome, and what preparation mistakes eliminate timing benefits before the peptide ever reaches circulation