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Coombes BK, et al

The smaller size of NPs enables higher permeability of cell membranes to interact with organelles such as mitochondria, lysosomes, and nucleus, finally causing cell damage ( 2 ) NPs correlated with their cytotoxicity (Kim et al., 2014

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In Phase I, our main goals will be safety and proving the drug is hitting its target the FAK-paxillin complex in fibrotic liver tissue. Though reversing fibrosis takes time, the researchers are also working to identify biomarkers of target engagement, which could accelerate clinical progress

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