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Emerging data also implicate gut-derived hormonessuch as glucagon-like peptide-1 (GLP-1), Peptide YY (PYY), and gastric inhibitory polypeptide (GIP)in the neuroendocrine regulation of bone remodeling

Alterations to NAD + metabolism and/or decline in tissue NAD + levels are directly related to m -Dys and pathological conditions such as CVD 521

Therefore, ALA could be considered an effective intervention against SARS-CoV-2 as well as a potent redoxeutical to resolve m -Dys-associated clinical manifestations in COVID-19 and PASC 532,533