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We therefore chose a region in FOXO4 that is conserved in both humans and mice, but differs from FOXO1 and FOXO3 (Fig

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Because pulmonary hypertension is common in COPD [130], it is possible that PB1046 will be of clinical value in COPD

These natural compounds frequently exhibit multi-faceted mechanisms of action, encompassing the modulation of monoaminergic neurotransmission, augmentation of neurotrophic signaling pathways, anti-inflammatory properties, antioxidant functions, and regulation of the HPA axis

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