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Our research shows that the supplementation of melatonin can restore the expression of core glycolytic genes through metabolic reprogramming of glucose metabolism in porcine granulosa cells and mouse ovaries, respectively, thereby improving lactate production, further enhancing lactylation, and inhibiting ferroptosis

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It is unknown how these drugs affect endothelial function in MetS patients ( Estradiol increases NO generation and endothelial function

mentioned in the literature [72, 93]